Lew D J, Reed S I
Duke University Medical Center, Durham, North Carolina 27710, USA.
Curr Opin Genet Dev. 1995 Feb;5(1):17-23. doi: 10.1016/s0959-437x(95)90048-9.
A detailed description of the cytoskeletal rearrangements that orchestrate bud formation is beginning to emerge from studies on yeast morphogenesis. In this review, we focus on recent advances in our understanding of how the timing of these rearrangements is controlled. Dramatic changes in cell polarity that occur in G1 (polarization to the bud site), G2 (depolarization within the bud), and mitosis (repolarization to the mother/bud neck) are triggered by changes in the kinase activity of Cdc28, the universal regulator of cell cycle progression. The hunt for Cdc28 morphogenesis substrates is on.
关于协调芽形成的细胞骨架重排的详细描述正开始从酵母形态发生的研究中显现出来。在这篇综述中，我们聚焦于我们对这些重排的时间是如何被控制的理解方面的最新进展。在G1期（向芽位点极化）、G2期（芽内去极化）和有丝分裂期（向母细胞/芽颈重新极化）发生的细胞极性的显著变化是由细胞周期进程的通用调节因子Cdc28激酶活性的变化触发的。寻找Cdc28形态发生底物的工作正在进行。
