Hinds P W
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Curr Opin Genet Dev. 1995 Feb;5(1):79-83. doi: 10.1016/s0959-437x(95)90057-8.
Loss of the retinoblastoma protein, pRb, appears to have a role in several human tumor types. Mice lacking pRb have been produced as models of human disease, but have a different spectrum of affected tissues. Recent work shows that the tumorigenic effects of pRb may be revealed only after additional genetic alterations, such as loss of p53. New targets/effectors of pRb have been identified recently, and the system of kinases that inactivate pRb is proving to be complex.
视网膜母细胞瘤蛋白pRb的缺失似乎在多种人类肿瘤类型中发挥作用。已培育出缺乏pRb的小鼠作为人类疾病模型，但受影响的组织谱有所不同。最近的研究表明，pRb的致瘤作用可能只有在发生额外的基因改变（如p53缺失）后才会显现出来。最近已鉴定出pRb的新靶点/效应器，而且使pRb失活的激酶系统被证明是复杂的。
