Ng S T, Wu T C
Department of Obstetrics and Gynecology, School of Medicine, University of California at Los Angeles, USA.
Int J Fertil Menopausal Stud. 1995 Jan-Feb;40(1):29-33.
The present study evaluated the impact of continuous administration of gonadotropin-releasing hormone agonist (GnRH-a) following oocyte retrieval of oocyte donors in a donor oocyte program.
Six patients from a donor oocyte program who underwent controlled ovarian hyperstimulation with midluteal GnRH-a and human menotropin had more than 20 mature ovarian follicles and serum estradiol levels > or = 3,000 pg/mL on the day of human chorionic gonadotropin administration. These patients resumed the use of GnRH-a immediately following follicular aspiration. Three patients continued daily injection until the onset of next menses, while three took it irregularly, due to poor compliance.
Only one of the three patients who administered GnRH-a daily developed mild symptoms of ovarian hyperstimulation, and all resumed menstruation within 13 days following aspiration. All three patients who failed to comply, and used GnRH-a sporadically, developed symptoms of ovarian hyperstimulation and experienced delayed menstrual periods. One of these three patients required hospitalization.
Our data suggest that continuous postaspiration GnRH-a use may be beneficial for oocyte donors whose ovaries are hyperstimulated. Sporadic administration of GnRH-a is not effective and may delay the resumption of spontaneous menstruation.
本研究评估了在供卵项目中，卵母细胞供者取卵后持续使用促性腺激素释放激素激动剂（GnRH-a）的影响。
来自一个供卵项目的6名患者，在黄体中期使用GnRH-a和人促性腺激素进行控制性卵巢过度刺激，在注射人绒毛膜促性腺激素当天有超过20个成熟卵泡且血清雌二醇水平≥3000 pg/mL。这些患者在卵泡抽吸后立即恢复使用GnRH-a。3名患者持续每日注射直至下次月经来潮，而另外3名患者由于依从性差，不规则用药。
每日使用GnRH-a的3名患者中只有1名出现轻度卵巢过度刺激症状，且所有人在抽吸后13天内恢复月经。所有3名未依从且偶尔使用GnRH-a的患者出现卵巢过度刺激症状且月经推迟。这3名患者中有1名需要住院治疗。
我们的数据表明，取卵后持续使用GnRH-a可能对卵巢过度刺激的卵母细胞供者有益。偶尔使用GnRH-a无效，且可能延迟自然月经的恢复。
