Di Ilio C, Sacchetta P, Angelucci S, Zezza A, Tenaglia R, Aceto A
Istituto di Scienze Biochimiche, Facoltà di Medicina, Università G. D'Annunzio, Chieti, Italy.
Cancer Lett. 1995 May 4;91(1):19-23. doi: 10.1016/0304-3835(95)03710-e.
Selenium-dependent (Se-GSH-Px), selenium-independent (non-Se-GSH-Px) glutathione peroxidase and glutathione reductase (GSSG-Rx) activities have been determined in cancerous and non-cancerous human adult kidney. Large inter-individual variation in the activities of all enzymes tested were found in both tumour and non-tumour specimens. In general a significant decrease in the activities of the three enzymes was found in tumours. When a comparison was made between cancerous and non-cancerous tissues of the same individual, Se-GSH-Px activity was found to be lower in tumour in 17 cases out of 29, and the non-Se-GSH-Px activity in 20. In 20 cases out of 29 GSSG-Rx was found to be lower in tumour. It was concluded that changes in the factors involved in the anti-oxidative protection actually occur in human kidney tumour.
已测定了人类成年肾脏癌组织和非癌组织中硒依赖性谷胱甘肽过氧化物酶（Se-GSH-Px）、非硒依赖性谷胱甘肽过氧化物酶（non-Se-GSH-Px）以及谷胱甘肽还原酶（GSSG-Rx）的活性。在肿瘤和非肿瘤标本中，所检测的所有酶的活性均存在较大的个体间差异。总体而言，肿瘤中这三种酶的活性显著降低。当对同一个体的癌组织和非癌组织进行比较时，发现29例中有17例肿瘤组织中的Se-GSH-Px活性较低，20例中的非Se-GSH-Px活性较低。29例中有20例肿瘤组织中的GSSG-Rx活性较低。得出的结论是，人类肾脏肿瘤中抗氧化保护相关因子确实发生了变化。
