结合患者斑贴试验与化学分析鉴定过敏性接触性皮炎的致病化学物质。应用于橡胶手套相关病例。
Identification of causative chemicals of allergic contact dermatitis using a combination of patch testing in patients and chemical analysis. Application to cases from rubber gloves.
作者信息
Kaniwa M, Isama K, Nakamura A, Kantoh H, Hosono K, Itoh M, Shibata K, Usuda T, Asahi K, Osada T
机构信息
National Institute of Hygienic Sciences, Tokyo, Japan.
出版信息
Contact Dermatitis. 1994 Aug;31(2):65-71. doi: 10.1111/j.1600-0536.1994.tb01920.x.
5 cases of allergic contact dermatitis from rubber gloves were investigated by our recommended procedures using a combination of patch testing in patients and chemical analysis of causative rubber products by gas chromatography (GC) and high-performance liquid chromatography (HPLC). We previously confirmed that zinc ethylphenyldithiocarbamate (ZEPC), a dithiocarbamae-type accelerator (DTC), was causative in a case of allergic contact dermatitis from rubber work gloves. Subsequently, we have clarified that DTCs such as zinc dimethyldithiocarbamate (ZDMC), zinc diethyldithiocarbamate (ZDEC) and zinc dibutyldithiocarbamate (ZDBC) and amines such as dimethylamine (DMA), diethylamine (DEA) and piperidine (PIP) were also causative in cases from surgical rubber gloves. Thus, our investigative studies revealed that, although thiurams have been taken much more notice of as allergenic compounds than their corresponding DTCs and amines, not only DTCs such as ZDMC, ZDEC, ZDBC and ZEPC, but also amines such as DMA, DEA and PIP were noteworthy causative candidates of allergic contact dermatitis from rubber gloves.
我们采用推荐的程序，通过对患者进行斑贴试验以及运用气相色谱（GC）和高效液相色谱（HPLC）对致病橡胶制品进行化学分析，对5例橡胶手套引起的过敏性接触性皮炎病例展开了调查。我们之前已证实，二硫代氨基甲酸盐类促进剂（DTC）乙基苯基二硫代氨基甲酸锌（ZEPC）是一例橡胶工作手套引起的过敏性接触性皮炎的致病因素。随后，我们又明确了二甲基二硫代氨基甲酸锌（ZDMC）、二乙基二硫代氨基甲酸锌（ZDEC）和二丁基二硫代氨基甲酸锌（ZDBC）等DTC以及二甲胺（DMA）、二乙胺（DEA）和哌啶（PIP）等胺类物质也是手术橡胶手套引起的病例的致病因素。因此，我们的调查研究表明，尽管秋兰姆作为致敏化合物比其相应的DTC和胺类受到了更多关注，但不仅ZDMC、ZDEC、ZDBC和ZEPC等DTC，而且DMA、DEA和PIP等胺类物质也是橡胶手套引起过敏性接触性皮炎值得关注的致病候选因素。
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