Koch P, Bahmer F A
Hautklinik der Universität des Saarlandes, Homburg/Saar, Germany.
Contact Dermatitis. 1994 Aug;31(2):97-101. doi: 10.1111/j.1600-0536.1994.tb01926.x.
4 patients developed an erythema-multiforme-like reaction following acute contact dermatitis from 2 different bufexamac-containing topical preparations. Histologically, the lesions did not show changes that were typical of erythema multiforme. Patch testing gave positive reactions to bufexamac at 1, 2, 3 and 4 days. The histological picture of 2 positive test reactions was suggestive of a drug reaction in the 1st, and of an acute eczematous reaction in the 2nd, case. A systemic allergic reaction with spread of lesions could have been involved, following percutaneous absorption of the allergen.
4例患者在使用两种不同的含丁苯羟酸外用制剂引发急性接触性皮炎后出现了多形红斑样反应。组织学上，这些皮损未表现出多形红斑的典型变化。斑贴试验在第1、2、3和4天对丁苯羟酸均呈阳性反应。2例阳性试验反应的组织学表现，第1例提示为药物反应，第2例提示为急性湿疹样反应。经皮吸收变应原后，可能涉及了伴有皮损扩散的全身性过敏反应。
