口服避孕药导致血浆11-脱氢血栓素B2水平大幅升高。

Large increase in plasmatic 11-dehydro-TxB2 levels due to oral contraceptives.

作者信息

Schlit A F, Grandjean P, Donnez J, Lavenne E

机构信息

Haemostasis Unit, Saint-Luc University Hospital, Brussels, Belgium.

出版信息

Contraception. 1995 Jan;51(1):53-8. doi: 10.1016/0010-7824(94)00002-e.

DOI:10.1016/0010-7824(94)00002-e

PMID:7750285

Abstract

Coagulation factors, 11-dehydro-TxB2 (metabolite of TxA2) and 6-keto-PGF1 alpha (metabolite of PGI2) levels in 87 women who were treated for 9 months with oral contraceptives (OC) containing low doses of oestrogens and progestogens (Triquilar, Trinovum or Cilest) were investigated. In plasma, increases in F I, II, VII, VIII-c and 11-dehydro-TxB2 levels, but no modification of 6-keto-PGF1 alpha were observed. In urine, FPA concentration rose, but no change occurred in 11-dehydro-TxB2 and 6-keto-PGF1 alpha levels. No marked difference between the 3 OC preparations were noted. These data, and particularly the large increase of 11-dehydro-TxB2 (p < 0.01) suggest that a hypercoagulable state persists in low dosage OC users.

摘要

对87名服用低剂量雌激素和孕激素口服避孕药（OC）（炔诺酮三相片、复方炔诺酮片或炔雌醇环丙孕酮片）9个月的女性的凝血因子、11-脱氢血栓素B2（血栓素A2的代谢产物）和6-酮-前列环素F1α（前列环素I2的代谢产物）水平进行了研究。在血浆中，观察到纤维蛋白原I、II、VII、VIII-c和11-脱氢血栓素B2水平升高，但6-酮-前列环素F1α无变化。在尿液中，纤维蛋白肽A浓度升高，但11-脱氢血栓素B2和6-酮-前列环素F1α水平无变化。三种OC制剂之间未观察到明显差异。这些数据，尤其是11-脱氢血栓素B2的大幅升高（p < 0.01）表明，低剂量OC使用者存在高凝状态。