Tartaglione A, Bandini F, Maculotti M, Marogna M, Spadavecchia L, Favale E
Laboratorio di Neuropsicologia, Clinica Neurologica, Università di Genova, Italy.
Electroencephalogr Clin Neurophysiol. 1995 May;96(3):197-205. doi: 10.1016/0168-5597(94)00333-a.
In a group of 27 demented patients (21 with DAT and 6 with MID) with normal pattern VEP (PVEP), the latencies of the main flash VEP (FVEP) components (P1, N2, P2 and N3) were assessed both with open and closed eyes. At variance from controls, demented patients showed that both P2 and N3 components are significantly delayed with closed eyes while neither P1 nor N2 timings are affected. Control studies ruled out the possibility that such an outcome might depend on a defective pupillary responsiveness and/or an impaired sensitivity to luminance changes. On these grounds it is suggested that the effect of mode of stimulation on FVEP latency in demented patients is more likely to depend on "central" than on "peripheral" mechanisms. The dependence of latency changes on closure of the eyes seems to negate the direct effect of lesions upon visual structures and suggests an impairment of the modulatory action of non-visual afferents upon the activity of the visual cortex.
在一组27名痴呆患者（21名患有阿尔茨海默病性痴呆和6名患有多发梗死性痴呆）中，其视觉诱发电位（VEP）模式正常（PVEP），对主要闪光视觉诱发电位（FVEP）成分（P1、N2、P2和N3）的潜伏期进行了睁眼和闭眼状态下的评估。与对照组不同，痴呆患者显示闭眼时P2和N3成分均显著延迟，而P1和N2的时间均未受影响。对照研究排除了这种结果可能取决于瞳孔反应性缺陷和/或对亮度变化的敏感性受损的可能性。基于这些理由，有人提出，刺激模式对痴呆患者FVEP潜伏期的影响更可能取决于“中枢”机制而非“外周”机制。潜伏期变化对闭眼的依赖性似乎否定了病变对视觉结构的直接影响，并提示非视觉传入对视觉皮层活动的调节作用受损。
