Aziz Q, Furlong P L, Barlow J, Hobson A, Alani S, Bancewicz J, Ribbands M, Harding G F, Thompson D G
Department of Gastroenterology, Hope Hospital, University of Manchester, UK.
Electroencephalogr Clin Neurophysiol. 1995 May;96(3):219-28. doi: 10.1016/0168-5597(94)00297-r.
We describe cortical potentials evoked by balloon distension of the proximal and distal oesophagus in 8 healthy right handed volunteers. Oesophageal stimulation was performed using a pump which rapidly inflated a 2 cm silicone balloon positioned either 3 cm distal to the upper oesophageal sphincter or 5 cm proximal to the lower oesophageal sphincter, at a frequency of 0.2 Hz, using inflation volumes which produced a definite but not painful sensation. Oesophageal evoked cortical potentials were recorded in all subjects with an initial negative and positive component (N1 and P1), followed by a second negative and positive component (N2 and P2) in 6 subjects. The morphology and the scalp topography of the N1 component elicited by proximal and distal oesophageal stimulation suggests activation of the primary somatosensory cortex and/or the insular. There was also evidence for hemispheric dominance for the N1 potential which was independent of handedness. The frontal emphasis of the proximal oesophageal N1 component, in contrast to the central emphasis of the distal oesophageal N1 component, suggests that different neuronal populations were activated by stimulation of the two sites. The frontal emphasis of the ensuing P1 component from both oesophageal sites suggests that it originates in a separate precentral source. The topography of the N2 components obtained by stimulation of either oesophageal site was similar to that of the N1 component, suggesting that they originate in similar areas of the cortex. The P2 component evoked by stimulation of both oesophageal sites was localised at the vertex. The inter- and intra-subject variation in the morphology of the N2 and P2 components suggests that secondary cortical processes related to cognition may be involved in their generation.
我们描述了8名健康右利手志愿者在近端和远端食管球囊扩张时诱发的皮质电位。使用一台泵进行食管刺激，该泵以0.2 Hz的频率，通过产生明确但不疼痛感觉的充气量，快速充胀一个位于食管上括约肌远端3 cm或食管下括约肌近端5 cm处的2 cm硅胶球囊。所有受试者均记录到食管诱发的皮质电位，初始为负向和正向成分（N1和P1），6名受试者随后出现第二个负向和正向成分（N2和P2）。近端和远端食管刺激诱发的N1成分的形态和头皮地形图表明初级体感皮层和/或岛叶被激活。也有证据表明N1电位存在半球优势，且与利手无关。与远端食管N1成分的中央部位相比，近端食管N1成分在额叶部位更为突出，这表明刺激这两个部位激活了不同的神经元群体。来自两个食管部位的后续P1成分在额叶部位更为突出，这表明它起源于中央前回的一个独立来源。通过刺激任一食管部位获得的N2成分的地形图与N1成分相似，表明它们起源于皮层的相似区域。刺激两个食管部位诱发的P2成分位于头顶。N2和P2成分形态在受试者间和受试者内的变化表明，与认知相关的二级皮层过程可能参与了它们的产生。
