Weusten B L, Lam H G, Akkermans L M, Van Berge-Henegouwen G P, Smout A J
Department of Gastroenterology, University Hospital Utrecht, The Netherlands.
Eur J Clin Invest. 1994 Sep;24(9):627-31. doi: 10.1111/j.1365-2362.1994.tb01115.x.
The recording of viscerosensory cerebral evoked potentials is a new field in the research on gastrointestinal perception. The aim of our study was to assess the relationships between age and peak amplitudes and latencies of cerebral potentials evoked by balloon distension of the human oesophagus. In 16 healthy volunteers (aged 21-59 years), cerebral evoked potentials were recorded from a midline scalp electrode, using a series of 50 rapid balloon inflations with 13 ml of air. Peak to peak amplitudes (N1-P1, P1-N2) and peak latencies (N1, P1, N2) were assessed. Inverse correlations were found between age and N1-P1 amplitude (P < 0.05), and between age and P1-N2 amplitudes (P < 0.05). N1 and P1 latencies were significantly longer in elderly patients (N1: P < 0.05; P1: P < 0.05). Amplitudes and peak latencies of cerebral potentials evoked by balloon distension of the oesophagus are age-dependent. In cerebral evoked potential studies, patients and healthy controls should be age-matched.
内脏感觉性脑诱发电位的记录是胃肠感知研究中的一个新领域。我们研究的目的是评估年龄与食管球囊扩张诱发的脑电位的峰值幅度和潜伏期之间的关系。在16名健康志愿者（年龄21 - 59岁）中，使用一系列50次快速向球囊内注入13毫升空气的操作，从头皮中线电极记录脑诱发电位。评估峰峰值幅度（N1 - P1、P1 - N2）和峰值潜伏期（N1、P1、N2）。发现年龄与N1 - P1幅度之间呈负相关（P < 0.05），年龄与P1 - N2幅度之间也呈负相关（P < 0.05）。老年患者的N1和P1潜伏期明显更长（N1：P < 0.05；P1：P < 0.05）。食管球囊扩张诱发的脑电位的幅度和峰值潜伏期与年龄有关。在脑诱发电位研究中，患者和健康对照应进行年龄匹配。
