Kamiya Y, Ito J, Fujii T, Horie K, Kawaguchi M, Hori R, Sakuma N, Fujinami T
Third Department of Internal Medicine, Nagoya City University Medical School, Japan.
Horm Metab Res. 1995 Apr;27(4):179-81. doi: 10.1055/s-2007-979934.
We previously reported that the octapeptide somatostatin (SS) analogue SMS 201-995 (SMS) unexpectedly stimulates the growth of A431 human epidermoid carcinoma cells in vitro. In the present study, we found that both SS-14 and SS-28 also stimulated the growth of A431 cells in vitro. The proliferative effect of SS-28 also stimulated the growth of A431 cells in vitro. The proliferative effect of SS-28 was greater than that of SS-14. In contrast, there was no difference in A431 cell tumor weight or area between the SMS-treated or untreated athymic, tumor-bearing mice. The serum epidermal growth factor (EGF) level of the SMS-treated mice was significantly lower than that of the untreated mice. Decreases in serum EGF may attenuate the proliferative effect of SMS in vivo.
我们之前报道过，八肽生长抑素（SS）类似物SMS 201-995（SMS）在体外出人意料地刺激了A431人表皮样癌细胞的生长。在本研究中，我们发现SS-14和SS-28在体外也能刺激A431细胞的生长。SS-28的增殖作用也能在体外刺激A431细胞的生长。SS-28的增殖作用大于SS-14。相比之下，在接受或未接受SMS治疗的无胸腺荷瘤小鼠中，A431细胞肿瘤重量或面积没有差异。接受SMS治疗的小鼠血清表皮生长因子（EGF）水平显著低于未治疗的小鼠。血清EGF的降低可能会减弱SMS在体内的增殖作用。
