Kamiya Y, Ohmura E, Arai M, Fujii T, Hayakawa F, Ito J, Kawaguchi M, Tsushima T, Sakuma N
Third Department of Internal Medicine, Nagoya University Medical School, Japan.
Biochem Biophys Res Commun. 1993 Feb 26;191(1):302-7. doi: 10.1006/bbrc.1993.1217.
Somatostatin (SS) and its analogue inhibit the growth of some human tumors in vivo. Surprisingly, we found that SS-14 and its analogue (SMS 201-995) exhibited unexpected proliferative effects on two lines of cells, A431 and KB human epidermoid carcinoma cells, in vitro. The level of intracellular cyclic AMP, an important second messenger that controls the growth of A431 cells, was unaffected in A431 cells by either SS-14 or SMS 201-995. In contrast, SS-14 (20 nM) and SMS 201-995 (10 nM) reduced the level of intracellular inositol 1,4,5-trisphosphate rapidly but transiently.
生长抑素（SS）及其类似物在体内可抑制某些人类肿瘤的生长。令人惊讶的是，我们发现SS - 14及其类似物（SMS 201 - 995）在体外对两株细胞系，即A431和KB人表皮样癌细胞，表现出意想不到的增殖作用。细胞内环状AMP是控制A431细胞生长的重要第二信使，其水平在A431细胞中不受SS - 14或SMS 201 - 995的影响。相反，SS - 14（20 nM）和SMS 201 - 995（10 nM）能迅速但短暂地降低细胞内肌醇1,4,5 - 三磷酸的水平。
