硝西泮的多态乙酰化作用。
Polymorphic acetylation of nitrazepam.
作者信息
Karim A K, Evans D A
出版信息
J Med Genet. 1976 Feb;13(1):17-9. doi: 10.1136/jmg.13.1.17.
Abstract
Nitrazepam is metabolized in part by nitro-reduction to an amine followed by acetylation. This acetylation step has been shown to be under the control of the same genetic polymorphism as sulphamethazine (syn: sulphadimidine).
摘要
硝西泮部分通过硝基还原代谢为胺，随后进行乙酰化。已证明该乙酰化步骤受与磺胺二甲嘧啶（同义词：磺胺二甲基嘧啶）相同的基因多态性控制。
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