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人类乙酰化酶多态性：利比亚等位基因频率估计及全球分布详情。

Human acetylator polymorphism: estimate of allele frequency in Libya and details of global distribution.

作者信息

Karim A K, Elfellah M S, Evans D A

出版信息

J Med Genet. 1981 Oct;18(5):325-30. doi: 10.1136/jmg.18.5.325.

DOI:10.1136/jmg.18.5.325
PMID:7328611
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1048751/
Abstract

Acetylator phenotyping by means of a sulphadimidine tests revealed 65% of Libyan Arabs to be slow acetylators. Hence the frequency of the allele controlling slow acetylation (As) is estimated as q = 0.81 +/- 0.05. This estimate is similar to those previously recorded in European and adjacent Middle Eastern populations.

摘要

通过磺胺二甲嘧啶试验进行乙酰化酶表型分析显示，65%的利比亚阿拉伯人是慢乙酰化者。因此，控制慢乙酰化的等位基因（As）的频率估计为q = 0.81±0.05。这一估计与先前在欧洲和邻近中东人群中记录的结果相似。

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本文引用的文献

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GENETICS OF ISONIAZID METABOLISM IN CAUCASIAN, NEGRO, AND JAPANESE POPULATIONS.高加索人、黑人和日本人中异烟肼代谢的遗传学
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A STUDY OF THE INFLUENCE OF THE ISONIAZID INACTIVATOR PHENOTYPE ON REVERSION IN GENITO-URINARY TUBERCULOSIS.
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[PROBLEMS OF ISONIAZID METABOLISM. HEREDITARY CHARACTER AND VARIABILITY ACCORDING TO RACES].[异烟肼代谢的问题。种族遗传性及变异性]
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FURTHER OBSERVATIONS ON TRIMODALITY OF FREQUENCY DISTRIBUTION CURVE OF BIOLOGICALLY ACTIVE ISONIAZID BLOOD LEVELS AND "CLINE" INFREQUENCIES OF ALLELES CONTROLLING ISONIAZID INACTIVATION.关于生物活性异烟肼血药浓度频率分布曲线的三峰性以及控制异烟肼失活的等位基因“渐变群”频率的进一步观察
Acta Tuberc Pneumol Scand. 1963;43:181-95.
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Rate of inactivation of isoniazid in South Indian patients with pulmonary tuberculosis.南印度肺结核患者中异烟肼的失活率
Bull World Health Organ. 1961;25(6):765-77.
7
[The blood level of INH in adults and children].[成人及儿童体内异烟肼的血药浓度]
Beitr Klin Tuberk Spezif Tuberkuloseforsch. 1960;122:239-50.
8
A comparison between the behavior of Eskimos and non-Eskimos to the administration of isoniazid.爱斯基摩人与非爱斯基摩人对异烟肼给药的行为比较。
Am Rev Respir Dis. 1960 Apr;81:588-94. doi: 10.1164/arrd.1960.81.4.588.
9
Peripheral neuritis due to isoniazid.异烟肼所致周围神经炎
Bull World Health Organ. 1960;23(4-5):587-98.
10
The frequency of isoniazid acetylase enzyme deficiency among Egyptians.埃及人中亚胺培南乙酰化酶缺乏症的发生率。 （注：原文可能有误，isoniazid是异烟肼，不是亚胺培南，正确译文应该是：埃及人异烟肼乙酰化酶缺乏症的发生率。）
Am J Phys Anthropol. 1969 Jul;31(1):97-101. doi: 10.1002/ajpa.1330310114.