人类乙酰化酶多态性：利比亚等位基因频率估计及全球分布详情。
Human acetylator polymorphism: estimate of allele frequency in Libya and details of global distribution.
作者信息
Karim A K, Elfellah M S, Evans D A
出版信息
J Med Genet. 1981 Oct;18(5):325-30. doi: 10.1136/jmg.18.5.325.
Abstract
Acetylator phenotyping by means of a sulphadimidine tests revealed 65% of Libyan Arabs to be slow acetylators. Hence the frequency of the allele controlling slow acetylation (As) is estimated as q = 0.81 +/- 0.05. This estimate is similar to those previously recorded in European and adjacent Middle Eastern populations.
摘要
通过磺胺二甲嘧啶试验进行乙酰化酶表型分析显示，65%的利比亚阿拉伯人是慢乙酰化者。因此，控制慢乙酰化的等位基因（As）的频率估计为q = 0.81±0.05。这一估计与先前在欧洲和邻近中东人群中记录的结果相似。
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本文引用的文献
1
2
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Science. 1964 Jul 24;145(3630):391.
3
A STUDY OF THE INFLUENCE OF THE ISONIAZID INACTIVATOR PHENOTYPE ON REVERSION IN GENITO-URINARY TUBERCULOSIS.
Tubercle. 1964 Jun;45:136-43. doi: 10.1016/s0041-3879(64)80071-4.
4
[PROBLEMS OF ISONIAZID METABOLISM. HEREDITARY CHARACTER AND VARIABILITY ACCORDING TO RACES].[异烟肼代谢的问题。种族遗传性及变异性]
Med Thorac. 1963;20:289-312.
5
6
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Bull World Health Organ. 1961;25(6):765-77.
7
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Beitr Klin Tuberk Spezif Tuberkuloseforsch. 1960;122:239-50.
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Am Rev Respir Dis. 1960 Apr;81:588-94. doi: 10.1164/arrd.1960.81.4.588.
9
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10
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