Bronsky E A, Druce H, Findlay S R, Hampel F C, Kaiser H, Ratner P, Valentine M D, Wood C C
J Allergy Clin Immunol. 1995 May;95(5 Pt 2):1117-22. doi: 10.1016/s0091-6749(95)70215-6.
Intranasal ipratropium bromide has been shown to significantly reduce rhinorrhea. Use of a freon-propelled intranasal preparation has resulted in side effects associated with the drying properties of the propellant. The purpose of the present trial was to study the safety and efficacy of a new isotonic aqueous ipratropium bromide nasal spray pump, specifically in patients with perennial nonallergic rhinitis. Two hundred thirty-three patients participated in an 8-week double-blind parallel comparison of ipratropium bromide nasal spray with its vehicle, a saline solution. Treatment with the ipratropium spray resulted in a 30% reduction in rhinorrhea; this reduction was significantly greater than that seen with the saline vehicle. There was a modest reduction in postnasal drip, sneezing, and congestion with both treatments, which may be attributable to the salutary effects of the saline solution. Patients also perceived a significant reduction in the degree to which rhinorrhea interfered with their daily activities and moods. Treatment was well tolerated, with no drug-related systemic adverse events and no evidence of nasal rebound on discontinuation of treatment. Minor, infrequent episodes of nasal dryness and epistaxis were the only significant adverse events reported; these did not limit treatment.
已证明鼻用异丙托溴铵可显著减少鼻分泌物。使用氟利昂推进的鼻用制剂会产生与推进剂干燥特性相关的副作用。本试验的目的是研究一种新的等渗水性异丙托溴铵鼻喷雾剂的安全性和有效性，特别是在常年性非过敏性鼻炎患者中。233名患者参与了为期8周的异丙托溴铵鼻喷雾剂与其赋形剂（一种盐溶液）的双盲平行比较。使用异丙托溴铵喷雾剂治疗可使鼻分泌物减少30%；这种减少显著大于使用盐溶液赋形剂时的减少。两种治疗方法均使鼻后滴漏、打喷嚏和鼻塞有适度减少，这可能归因于盐溶液的有益作用。患者还感觉鼻分泌物对其日常活动和情绪的干扰程度显著降低。治疗耐受性良好，未出现与药物相关的全身性不良事件，且停药时无鼻反弹迹象。报告的唯一显著不良事件是轻微、偶发的鼻干燥和鼻出血；这些并未限制治疗。
