Gak J C, Graillot C, Truhaut R
Lab Anim Sci. 1976 Apr;26(2 Pt 2):274-80.
The choice of an appropriate species and strain of laboratory animal is one of the toxicologist's major concerns. The biochemical, anatomical, and other characteristics of the golden hamster which make it a valuable though limited tool in toxicologic research were reviewed. The effects of organochloride insecticides on rats, mice, and hamsters were compared. These substances can be classified into 3 groups based on the hamster's sensitivity to acute toxic effects. The hamster is so insensitive to DDT and its immediate metabolites, DDD and DDE, that an LD50 cannot be established, whereas the hamster's sensitivity to other organochlorides varies when compared with mouse and rat sensitivity. The long-term effects of sub-lethal doses of organochloride insecticides on biochemical pathways were evaluated, particularly on liver function. The details of the induction of drug-metabolizing enzymes in the hamster and in the rat were also explored.
选择合适的实验动物物种和品系是毒理学家主要关注的问题之一。本文综述了金黄仓鼠的生化、解剖学及其他特性，这些特性使其成为毒理学研究中有价值但有限的工具。比较了有机氯杀虫剂对大鼠、小鼠和仓鼠的影响。根据仓鼠对急性毒性作用的敏感性，这些物质可分为3组。仓鼠对滴滴涕及其直接代谢产物滴滴滴和滴滴伊非常不敏感，以至于无法确定其半数致死剂量，而与小鼠和大鼠的敏感性相比，仓鼠对其他有机氯的敏感性有所不同。评估了亚致死剂量的有机氯杀虫剂对生化途径的长期影响，特别是对肝功能的影响。还探讨了仓鼠和大鼠中药物代谢酶诱导的细节。
