Martorana P A
Lab Anim Sci. 1976 Apr;26(2 Pt 2):352-4.
The Syrian hamster was chosen as an animal model for experimental studies of papain aerosol-induced emphysema. The extent of the developed lesions correlated with concentration of papain and progressed with time following exposure. The same correlations of dose and time were similar to those found in man and were evaluated physiologically and histologically. The intratracheal administration of alpha1-antitrypsin prior to exposure to the single dose of papain aerosol prevented the development of lesions, whereas systemic administration of alpha1-antitrypsin did not.
叙利亚仓鼠被选为木瓜蛋白酶气雾剂诱导肺气肿实验研究的动物模型。所形成病变的程度与木瓜蛋白酶的浓度相关，并在接触后随时间进展。剂量和时间的相同相关性与在人类中发现的相似，并通过生理学和组织学进行评估。在单次接触木瓜蛋白酶气雾剂之前气管内给予α1-抗胰蛋白酶可预防病变的发展，而全身给予α1-抗胰蛋白酶则不能。
