Basmadzhieva K, Kolev K, Balabaeva L
Eksp Med Morfol. 1981;20(2):113-7.
The authors formed lung emphysema in white rats under experimental conditions by intratracheal application of various concentrations of papaine at different intervals. In the performed experiment the most suitable dose for formation of emphysema was two fold administration of 2 milligrams of papaine. The following indices were observed in the experimental and control animals: body weight, weight coefficient of the internal organs, indices of lipid and nucleinic metabolism in homogenates of lung as well as histomorphologic examination of lung.
作者通过在不同时间间隔经气管给予不同浓度的木瓜蛋白酶，在实验条件下使白鼠形成肺气肿。在进行的实验中，形成肺气肿的最适宜剂量是给予2毫克木瓜蛋白酶，分两次给药。对实验动物和对照动物观察了以下指标：体重、内脏重量系数、肺匀浆中脂质和核酸代谢指标以及肺的组织形态学检查。
