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进行性骨化性纤维发育不良患儿在接种白喉-破伤风-百日咳疫苗后注射部位出现永久性异位骨化。

Permanent heterotopic ossification at the injection site after diphtheria-tetanus-pertussis immunizations in children who have fibrodysplasia ossificans progressiva.

作者信息

Lanchoney T F, Cohen R B, Rocke D M, Zasloff M A, Kaplan F S

机构信息

Department of Orthopedic Surgery, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.

出版信息

J Pediatr. 1995 May;126(5 Pt 1):762-4. doi: 10.1016/s0022-3476(95)70408-6.

DOI:10.1016/s0022-3476(95)70408-6
PMID:7752003
Abstract

In patients who have fibrodysplasia ossificans progressiva, routine childhood diphtheria-tetanus-pertussis immunizations administered by intramuscular injection caused a significant risk of permanent heterotopic ossification at the site of injection (p < 10(-8)), whereas measles-mumps-rubella immunizations administered by subcutaneous injection posed no significant risk. Intramuscular injections should be avoided, if possible, once a diagnosis of fibrodysplasia ossificans progressiva has been established.

摘要

在患有进行性骨化性纤维发育不良的患者中，通过肌肉注射进行的常规儿童白喉-破伤风-百日咳免疫接种在注射部位导致永久性异位骨化的风险显著（p < 10(-8)），而通过皮下注射进行的麻疹-腮腺炎-风疹免疫接种则无显著风险。一旦确诊为进行性骨化性纤维发育不良，应尽可能避免肌肉注射。

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