胰岛素依赖型糖尿病母亲足月产婴儿宫内骨吸收增加的证据。
Evidence of increased intrauterine bone resorption in term infants of mothers with insulin-dependent diabetes.
作者信息
Demarini S, Specker B L, Sierra R I, Miodovnik M, Tsang R C
机构信息
Department of Pediatrics, University of Cincinnati Medical Center, OH 45267-0541, USA.
出版信息
J Pediatr. 1995 May;126(5 Pt 1):796-8. doi: 10.1016/s0022-3476(95)70414-0.
Infants of diabetic mothers (IDMs) have lower bone mineral content than control subjects at birth. We measured cord blood propeptide of type I procollagen (PICP), a marker of bone formation, and telopeptide of type I collagen (ICTP), a marker of bone resorption, in 25 term IDMs and 20 term control subjects. Concentrations of ICTP were higher in IDMs than in control subjects; there was no difference in PICP concentrations. We conclude that osteoclastic activity appears to be higher in IDMs than in control subjects in utero.
糖尿病母亲的婴儿（IDMs）在出生时骨矿物质含量低于对照组。我们测量了25名足月IDMs和20名足月对照组受试者的脐血I型前胶原前肽（PICP，一种骨形成标志物）和I型胶原端肽（ICTP，一种骨吸收标志物）。IDMs的ICTP浓度高于对照组；PICP浓度无差异。我们得出结论，宫内IDMs的破骨细胞活性似乎高于对照组。
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