LeLorier J
Centre de Recherche, Hôtel-Dieu de Montréal Hospital, PQ, Canada.
J Rheumatol Suppl. 1995 Feb;43:26-7.
Peptic ulcer complications constitute the most important undesirable side effect of nonsteroidal antiinflammatory drugs (NSAID). The object of this study was to use the coprescription of a non-aspirin NSAID (NANSAID) and misoprostol or another antiulcer agent (AUA) as an endpoint to estimate the difference in the toxicity of ibuprofen compared to other available NANSAID. We also compared demographic characteristics of these 2 groups of patients. The study was done on the Quebec Health Insurance Board (RAMQ) database. The patients treated with ibuprofen are perceived by their physicians as having a lower need for AUA than those treated with other NANSAID. However, since patients treated with ibuprofen are younger, have fewer comedications, a lower frequency of medical visits, a lower frequency of arthritis, and a more occasional pattern of use, their lesser need for AUA might be due to a channelling of low risk patients toward this drug.
消化性溃疡并发症是非甾体抗炎药（NSAID）最重要的不良副作用。本研究的目的是将非阿司匹林类NSAID（NANSAID）与米索前列醇或其他抗溃疡药物（AUA）联合处方作为一个终点指标，以评估布洛芬与其他可用NANSAID相比在毒性方面的差异。我们还比较了这两组患者的人口统计学特征。该研究基于魁北克医疗保险委员会（RAMQ）数据库进行。与使用其他NANSAID治疗的患者相比，使用布洛芬治疗的患者被其医生认为对AUA的需求较低。然而，由于使用布洛芬治疗的患者更年轻，合并用药更少，就诊频率更低，关节炎发生率更低，且用药模式更不频繁，他们对AUA需求较低可能是因为低风险患者被引导使用了这种药物。
