Lohmander L S
Department of Orthopedics, University Hospital, Lund, Sweden.
J Rheumatol Suppl. 1995 Feb;43:75-7.
Aggrecan fragments are released from human joint cartilage matrix into joint fluid after injury and in osteoarthritis (OA). The temporal patterns of release agree with changes in synthesis and degradation of aggrecan found in experimental animal models of OA. However, we are far from being able to use these molecular fragments to monitor human OA. The structures of the aggrecan fragments remaining in cartilage, and of those being released into joint fluid after cleavage, are consistent with more than one proteolytic agent being active in human joint cartilage after joint injury and in OA.
在损伤后以及骨关节炎（OA）中，聚集蛋白聚糖片段从人类关节软骨基质释放到关节液中。释放的时间模式与OA实验动物模型中聚集蛋白聚糖合成和降解的变化一致。然而，我们远不能利用这些分子片段来监测人类OA。留在软骨中的聚集蛋白聚糖片段以及裂解后释放到关节液中的片段的结构表明，在关节损伤后和OA中，不止一种蛋白水解剂在人类关节软骨中起作用。
