Thonar E J, Masuda K, Lenz M E, Hauselmann H J, Kuettner K E, Manicourt D H
Department of Biochemistry, Rush Medical College, Chicago, IL 60612-3864, USA.
J Rheumatol Suppl. 1995 Feb;43:68-70.
Serum levels of several molecules originating from joints and cartilages have been shown to rise during the preradiological stages of osteoarthritis (OA). Using a dog model of posttraumatic OA, we have shown that serum levels of markers of aggrecan degradation (antigenic keratan sulfate) and synovial proliferation/metabolism (hyaluronan) rise within 1-2 weeks after the injury and remain elevated for at least 13 weeks. These changes, which precede the development of OA lesions, are consistent with the view that traumatic injury to a single synovial joint gives rise to a state of hypermetabolism that is local at first but becomes systemic with time.
在骨关节炎（OA）的放射学前阶段，源自关节和软骨的几种分子的血清水平已被证明会升高。使用创伤后OA的犬模型，我们已经表明，聚集蛋白聚糖降解标志物（抗原性硫酸角质素）和滑膜增殖/代谢标志物（透明质酸）的血清水平在损伤后1-2周内升高，并至少持续升高13周。这些在OA病变发展之前出现的变化，与以下观点一致：单个滑膜关节的创伤性损伤会引发一种高代谢状态，这种状态起初是局部性的，但随着时间的推移会变为全身性的。
