Brook I
Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA.
J Med Microbiol. 1995 May;42(5):340-7. doi: 10.1099/00222615-42-5-340.
From 1974 to 1994, 504 isolates of Prevotella and Porphyromonas spp. were obtained from 435 (21%) of 2033 specimens from 418 children. They included 160 (32%) Pr. melaninogenica, 105 (21%) Pr. intermedia, 84 (17%) P. asaccharolytica, 58 (12%) Pr. orisbuccae, and 58 (12%) Pr. oralis. Most Prevotella and Porphyromonas spp. were isolated from abscesses (176), pulmonary infections (85), ear infections (82), wound infections (44), peritonitis (38), paronychia (15) and chronic sinusitis (14). Predisposing conditions were noted in 111 (27%) of the cases; these included previous surgery in 41 (10%), foreign body in 36 (9%), neurological deficiencies in 29 (7%), immunodeficiency in 21 (5%), steroid therapy in 12 (4%), diabetes in 8 (2%) and malignancy in 7 (2%). Prevotella and Porphyromonas spp. were the only isolates in 14 (3%) patients, and mixed infection was encountered in 404 (97%). The micro-organisms most commonly isolated with Prevotella and Porphyromonas spp. were anaerobic cocci (393 isolates), Fusobacterium spp. (108), Bacteroides spp. (B. fragilis group) (95), Escherichia coli (56) and other gram-negative anaerobic bacilli (52). Most Bacteroides spp. and E. coli were isolated from intra-abdominal infections and skin and soft tissue infections around the rectal area, whereas most Fusobacterium spp. were isolated from oropharyngeal, pulmonary and head and neck sites. beta-Lactamase production was detected in 191 (38%) Prevotella and Porphyromonas isolates from all body sites. All patients received antimicrobial therapy, and surgical drainage was performed in 173 (41%) cases. Four patients died from their infection. These data illustrate the spectrum and importance of Prevotella and Porphyromonas spp. in infections in children.
1974年至1994年期间，从418名儿童的2033份标本中的435份（21%）中分离出504株普雷沃菌属和卟啉单胞菌属菌株。其中包括160株（32%）产黑色素普雷沃菌、105株（21%）中间普雷沃菌、84株（17%）不解糖卟啉单胞菌、58株（12%）口腔普雷沃菌和58株（12%）口普雷沃菌。大多数普雷沃菌属和卟啉单胞菌属菌株分离自脓肿（176例）、肺部感染（85例）、耳部感染（82例）、伤口感染（44例）、腹膜炎（38例）、甲沟炎（15例）和慢性鼻窦炎（14例）。111例（27%）病例存在易感因素；其中包括既往手术史41例（10%）、异物36例（9%）、神经功能缺陷29例（7%）、免疫缺陷21例（5%）、类固醇治疗12例（4%）、糖尿病8例（2%）和恶性肿瘤7例（2%）。普雷沃菌属和卟啉单胞菌属是14例（3%）患者的唯一分离菌株，404例（97%）患者存在混合感染。最常与普雷沃菌属和卟啉单胞菌属一起分离出的微生物是厌氧球菌（393株）、梭杆菌属（108株）、拟杆菌属（脆弱拟杆菌群）（95株）、大肠埃希菌（56株）和其他革兰氏阴性厌氧杆菌（52株）。大多数拟杆菌属和大肠埃希菌分离自腹腔内感染以及直肠周围的皮肤和软组织感染，而大多数梭杆菌属分离自口咽部、肺部以及头颈部部位。在所有身体部位的191株（38%）普雷沃菌属和卟啉单胞菌属分离菌株中检测到β-内酰胺酶产生。所有患者均接受了抗菌治疗，173例（41%）病例进行了手术引流。4例患者死于感染。这些数据说明了普雷沃菌属和卟啉单胞菌属在儿童感染中的范围和重要性。
