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在补充营养抗氧化剂、必需脂肪酸和辅酶Q10的“高危”患者中,乳腺癌出现明显部分缓解。

Apparent partial remission of breast cancer in 'high risk' patients supplemented with nutritional antioxidants, essential fatty acids and coenzyme Q10.

作者信息

Lockwood K, Moesgaard S, Hanioka T, Folkers K

机构信息

Private Outpatient Clinic, Copenhagen, Denmark.

出版信息

Mol Aspects Med. 1994;15 Suppl:s231-40. doi: 10.1016/0098-2997(94)90033-7.

Abstract

Thirty-two typical patients with breast cancer, aged 32-81 years and classified 'high risk' because of tumor spread to the lymph nodes in the axilla, were studied for 18 months following an Adjuvant Nutritional Intervention in Cancer protocol (ANICA protocol). The nutritional protocol was added to the surgical and therapeutic treatment of breast cancer, as required by regulations in Denmark. The added treatment was a combination of nutritional antioxidants (Vitamin C: 2850 mg, Vitamin E: 2500 iu, beta-carotene 32.5 iu, selenium 387 micrograms plus secondary vitamins and minerals), essential fatty acids (1.2 g gamma linolenic acid and 3.5 g n-3 fatty acids) and Coenzyme Q10 (90 mg per day). The ANICA protocol is based on the concept of testing the synergistic effect of those categories of nutritional supplements, including vitamin Q10, previously having shown deficiency and/or therapeutic value as single elements in diverse forms of cancer, as cancer may be synergistically related to diverse biochemical dysfunctions and vitamin deficiencies. Biochemical markers, clinical condition, tumor spread, quality of life parameters and survival were followed during the trial. Compliance was excellent. The main observations were: (1) none of the patients died during the study period. (the expected number was four.) (2) none of the patients showed signs of further distant metastases. (3) quality of life was improved (no weight loss, reduced use of pain killers). (4) six patients showed apparent partial remission.

摘要

32例典型乳腺癌患者,年龄在32至81岁之间,因肿瘤已扩散至腋窝淋巴结而被归类为“高危”患者,按照癌症辅助营养干预方案(ANICA方案)进行了为期18个月的研究。根据丹麦法规要求,营养方案被添加到乳腺癌的手术和治疗中。添加的治疗方法是营养抗氧化剂(维生素C:2850毫克,维生素E:2500国际单位,β-胡萝卜素32.5国际单位,硒387微克加辅助维生素和矿物质)、必需脂肪酸(1.2克γ-亚麻酸和3.5克n-3脂肪酸)和辅酶Q10(每天90毫克)的组合。ANICA方案基于这样一种概念,即测试这些营养补充剂类别的协同作用,包括辅酶Q10,这些营养补充剂先前已显示出在多种癌症中作为单一元素的缺乏和/或治疗价值,因为癌症可能与多种生化功能障碍和维生素缺乏存在协同关系。在试验期间对生化指标、临床状况、肿瘤扩散、生活质量参数和生存率进行了跟踪。依从性极佳。主要观察结果如下:(1)在研究期间没有患者死亡。(预期死亡人数为4人。)(2)没有患者出现进一步远处转移的迹象。(3)生活质量得到改善(体重未减轻,止痛药使用减少)。(4)6例患者出现明显的部分缓解。

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