University of Rijeka, Department of Biotechnology, Radmile Matejčić 2, HR-51000 Rijeka, Croatia.
Juraj Dobrila University of Pula, Faculty of Medicine, HR-52100 Pula, Croatia.
Molecules. 2020 May 8;25(9):2222. doi: 10.3390/molecules25092222.
Nutrigenomics is a discipline that studies the effects of various dietary components on gene expression and molecular mechanisms via "omics" technologies. Many studies are focused on revealing the pathways of the anticancer properties of various nutraceuticals. However, it has been shown that metastasis, a multifactorial disease that develops from primary tumors in cascades, is responsible for almost 90% of cancer deaths. Regrettably, the effects of consumption of different nutraceuticals on metastasis development have not yet been sufficiently explored. A few studies on the subject have revealed the promotional effects of some nutraceuticals on metastasis development. Additionally, it has been shown that certain compounds can have beneficial effects on reduction of the primary tumor, but afterwards promote the spread of metastases. Therefore, in this review we discuss results published in the past five years focused on the effects of different nutraceuticals on metastasis development.
营养基因组学是一门通过“组学”技术研究各种膳食成分对基因表达和分子机制影响的学科。许多研究都集中在揭示各种营养保健品抗癌特性的途径上。然而，已经表明，转移是一种多因素疾病，它是由原发性肿瘤级联发展而来，几乎占癌症死亡人数的 90%。遗憾的是，不同营养保健品对转移发展的影响尚未得到充分研究。一些关于这个主题的研究揭示了一些营养保健品对转移发展的促进作用。此外，已经表明某些化合物可以对减少原发性肿瘤有有益的影响，但随后会促进转移的扩散。因此，在这篇综述中，我们讨论了过去五年发表的关于不同营养保健品对转移发展影响的结果。
