Iyngkaran N, Yadav M, Boey C G
Department of Paediatrics, University Hospital, Kuala Lumpur.
Med J Malaysia. 1995 Mar;50(1):21-4.
The effect of cow's milk protein (CMP) challenge on the levels of alkaline phosphatase (ALP) in the upper jejunal mucosa and the serum were studied in 25 infants clinically suspected to have cow's milk allergy. Following CMP provocation 3 groups were identified. Group 1 consisted of 10 infants who had clinical and histological reaction to CMP challenge. All 10 infants had significant depletion in the levels of tissue and serum ALP. Group 2 consisted of 5 infants who had histological reaction but no clinical reaction. Tissue ALP was depressed in 3 but not in 2 following CMP challenge. Serum ALP were essentially unaltered in all 5. Group 3 consisted of 10 infants who clinically and histologically tolerated CMP challenge. Tissue and serum ALP were not depressed in any. Estimation of sucrase levels in the mucosa and xylose absorption before and after CMP challenge were also performed for comparison with changes of tissue and serum ALP levels. The clinical significance of the changes in serum ALP level is discussed.
在25名临床怀疑患有牛奶过敏的婴儿中，研究了牛奶蛋白（CMP）激发对空肠上段黏膜和血清中碱性磷酸酶（ALP）水平的影响。CMP激发后，确定了3组。第1组由10名对CMP激发有临床和组织学反应的婴儿组成。所有10名婴儿的组织和血清ALP水平均显著降低。第2组由5名有组织学反应但无临床反应的婴儿组成。CMP激发后，3名婴儿的组织ALP降低，2名未降低。所有5名婴儿的血清ALP基本未改变。第3组由10名在临床和组织学上耐受CMP激发的婴儿组成。组织和血清ALP均未降低。还进行了CMP激发前后黏膜中蔗糖酶水平和木糖吸收的测定，以与组织和血清ALP水平的变化进行比较。讨论了血清ALP水平变化的临床意义。
