Fukura K
First Department of Surgery, Kagoshima University of Medicine, Japan.
Nihon Geka Gakkai Zasshi. 1995 Apr;96(4):228-35.
The effect of pancreaticogastrostomy on Heidenhain pouch secretion in eight dogs was studied. The acid secretions collected at three sequential periods (0-6, 6-12, 12-24 hours) after meal increased significantly in the total amount secreted and particularly at 6-12 hours, p < 0.05. Secondly, after a 15 min initial collection of basal secretions, the animals were fed a meat meal and gastric juice from the pouch was collected every 15 minutes for 3 hours. Basal secretion of acid increased significantly, p < 0.05, but postprandial acid secretion did not increase. Serum gasrin and basal serum secretin levels did not increase markedly. Five hundred milligram of BT-PABA was given together with milk (40cc) and urine recovery of split-off PABA was measured over a 6-hour period. The median PABA recovery rate did not change markedly. Serum glucose and insulin response after oral administration of 1.5g/kg glucose were measured. Both responses did not show any remarkable change. It is suggested that pancreaticogastrostomy caused an increase in gastric secretion, but did not affect the pancreatic exocrine and endocrine function.
研究了胰胃吻合术对8只犬海登海因袋分泌的影响。餐后三个连续时间段（0 - 6小时、6 - 12小时、12 - 24小时）收集的胃酸分泌总量显著增加，特别是在6 - 12小时，p < 0.05。其次，在最初收集15分钟基础分泌液后，给动物喂食一顿肉餐，并在3小时内每隔15分钟收集袋中的胃液。基础胃酸分泌显著增加，p < 0.05，但餐后胃酸分泌未增加。血清胃泌素和基础血清促胰液素水平未明显升高。将500毫克对氨基苯甲酸（BT - PABA）与牛奶（40毫升）一起给予，并在6小时内测量分离出的对氨基苯甲酸的尿回收率。对氨基苯甲酸回收率中位数无明显变化。口服1.5克/千克葡萄糖后测量血清葡萄糖和胰岛素反应。两种反应均未显示任何显著变化。提示胰胃吻合术可导致胃酸分泌增加，但不影响胰腺外分泌和内分泌功能。
