Roles of gastrin release and neural reflexes during the gastric phase of acid secretion in dogs.

The acid secretion from the main stomachs and from denervated Heidenhain pouches in response to peptone meals infused in the stomach was determined in 4 dogs. When expressed as percent of the maximal acid response to histamine, the acid secretion from the innervated and from the denervated fundic mucosa was similar, but the response from the Heidenhain pouch was larger when expressed as percent of the maximal response to pentagastrin. These studies indicate that, under the conditions used, short (gastrogastric) and long (vagovagal) reflexes during the gastric phase, are of minor importance in inducing the acid response to the meal.