Piruzian E S, Alikhanian S I, Yaroslavtseva N G
Mutat Res. 1976 Apr;35(1):1-6. doi: 10.1016/0027-5107(76)90162-7.
Spontaneous and induced mutation frequencies of phage T4 have been measured in Escherichia coli strains containing altered RNA-polymerase. In the strain E. coli rif-r stl-r, with double RNA-polymerase mutation, spontaneous reversion rates were increased in different mutants of phage T4. The study of base analogues mutagenesis in rUV mutants of phage T4 has shown that the introduction of RNA-polymerase mutations did not increase reversion rates in a mutant of frame-shift type but enhanced the rate of mutagenesis in phage mutants with lesions of transition type.
在含有改变的RNA聚合酶的大肠杆菌菌株中，已对噬菌体T4的自发和诱导突变频率进行了测量。在具有双重RNA聚合酶突变的大肠杆菌rif-r stl-r菌株中，噬菌体T4的不同突变体的自发回复率有所增加。对噬菌体T4的rUV突变体中碱基类似物诱变的研究表明，RNA聚合酶突变的引入并未增加移码型突变体的回复率，但提高了具有转换型损伤的噬菌体突变体的诱变率。
