Piruzian E S, Alikhanian S I, Iaroslavtseva N G
Genetika. 1975;11(6):141-6.
Study was made of the frequency of induced and spontaneous mutations in phage T4 in RNA polymerase Escherichia coli strains. It has been shown that the rate of induced mutagenesis by base analogues increases in two rUV-mutants of phage T4 carrying mutations of the transition type, unlike the frameshift mutant which does not revert under these conditions. An increase in the level of spontaneous mutations in the phage is also found when RNA polymerase mutations are introduced into the system. The influence of mutant RNA polymerase on the mutation process is specific as no alteration of the recombination process in phage T4 has been found in E. coli strains with mutant RNA polymerase.
对噬菌体T4在RNA聚合酶大肠杆菌菌株中诱导突变和自发突变的频率进行了研究。结果表明，与在这些条件下不会回复的移码突变体不同，携带转换型突变的噬菌体T4的两个rUV突变体中，碱基类似物诱导诱变的速率增加。当将RNA聚合酶突变引入系统时，还发现噬菌体中自发突变水平有所增加。突变RNA聚合酶对突变过程的影响具有特异性，因为在具有突变RNA聚合酶的大肠杆菌菌株中未发现噬菌体T4重组过程有改变。
