Meikle A W, Stephenson R A, McWhorter W P, Skolnick M H, Middleton R G
Department of Medicine, University of Utah School of Medicine, Salt Lake City 84132, USA.
Prostate. 1995 May;26(5):253-9. doi: 10.1002/pros.2990260505.
Benign prostatic hyperplasia (BPH) and prostate cancer commonly occur together. This suggests that common familial, hormonal, and environmental factors contribute to their development. In men at risk for the development of prostate cancer (at 40 men in 19 families) and aged-matched unrelated controls (n = 46), we have determined whether familial factors, age, and blood hormone concentrations are related to the transition zone (TZ), peripheral zone (PZ), or total volume of the prostate measured by transrectal ultrasound (TRUS). We determined that the influences of age, prostate cancer (n = 15), and familial status did not significantly affect the relationships reported. Therefore, data from all groups were combined for this study. TZ correlated positively with age (P = 0.003) after controlling for family status, but total prostate volume correlated insignificantly with age (P = 0.08). In addition, the ratio of TZ to PZ volumes also correlated significantly with age in the control group (r = 0.27, P = 0.014). Both TZ and PZ volumes correlated highly (r = 0.91, P < 0.0001, n = 86) with total volume. In addition, total volume correlated significantly (r = 0.71, P < 0.001) with the ratio of the TZ/PZ volumes, which also correlated significantly with each other (r = 0.61, P < 0.0001, n = 86). In contrast to the increase of TZ volume related to total prostate volume, PZ volume declined compared with total volume. Prostate volumes up to 50 ml are predominated by the PZ and above 50 ml by the TZ, which may compress and shrink the PZ. Both TZ and total prostate volume correlated positively with serum estrone concentrations (P = 0.04 and P = 0.003, respectively). These results suggest that the risk of prostate cancer does not contribute to generalized overgrowth of the prostate, including the TZ. However, estrogens and age strongly influence TZ but not PZ volume. Both PZ and TZ volumes rise together until the prostate exceeds 50 ml, when the growth of the TZ appears to exceed the PZ and then to compress it.
良性前列腺增生（BPH）和前列腺癌常同时发生。这表明常见的家族、激素和环境因素促成了它们的发生发展。在有前列腺癌发病风险的男性（19个家族中的40名男性）以及年龄匹配的无血缘关系对照者（n = 46）中，我们确定了家族因素、年龄和血液激素浓度是否与经直肠超声（TRUS）测量的前列腺移行区（TZ）、外周区（PZ）或总体积相关。我们确定年龄、前列腺癌（n = 15）和家族状况的影响并未显著影响所报告的关系。因此，本研究将所有组的数据合并。在控制家族状况后，TZ与年龄呈正相关（P = 0.003），但前列腺总体积与年龄的相关性不显著（P = 0.08）。此外，在对照组中，TZ与PZ体积之比也与年龄显著相关（r = 0.27，P = 0.014）。TZ和PZ体积与总体积均高度相关（r = 0.91，P < 0.0001，n = 86）。此外，总体积与TZ/PZ体积之比显著相关（r = 0.71，P < 0.001），TZ/PZ体积之比彼此之间也显著相关（r = 0.61，P < 0.0001，n = 86）。与TZ体积随前列腺总体积增加不同，PZ体积与总体积相比有所下降。前列腺体积达50 ml及以下时以PZ为主，50 ml以上时以TZ为主，TZ可能会压迫并使PZ缩小。TZ和前列腺总体积均与血清雌酮浓度呈正相关（分别为P = 0.04和P = 0.003）。这些结果表明，前列腺癌风险并不会导致包括TZ在内的前列腺普遍过度生长。然而，雌激素和年龄对TZ体积有强烈影响，但对PZ体积无影响。PZ和TZ体积在前列腺超过50 ml之前共同增大，此时TZ的生长似乎超过PZ并对其产生压迫。
