对大鼠进行为期两周的4-叔丁基甲苯吸入暴露会导致其视觉诱发电位出现持续性变化。
Two weeks inhalation exposure to 4-tert-butyltoluene causes persistent changes in visually evoked potentials in rats.
作者信息
Lund S P, Simonsen L, Fries A S
机构信息
National Institute of Occupational Health, Copenhagen, Denmark.
出版信息
Pharmacol Toxicol. 1995 Jan;76(1):36-40. doi: 10.1111/j.1600-0773.1995.tb00099.x.
The effects of repeated exposure to 20 p.p.m. 4-tert-butyltoluene (CAS No. [98-51-1]) 6 hr/day for 14 days on the function of the intact nervous system were examined by measurements of flash evoked potentials in Wistar rats. The exposure to 4-tert-butyltoluene induced changes in the amplitudes of the flash evoked potentials. The changes were significantly different from controls on day 2, 19 and 26 after cessation of the exposure, but not on day 5 and 12. No significant difference in body weight gain between groups was found during the experiment. These results indicate that repeated exposure to 20 p.p.m. 4-tert-butyltoluene causes persistent changes in the function of the central nervous system measured as changes in the flash evoked potential. A reevaluation of the present TLV value of 10 p.p.m. for 4-tert-butyltoluene is suggested.
通过测量Wistar大鼠的闪光诱发电位，研究了每天6小时、连续14天反复接触20 ppm 4-叔丁基甲苯（化学物质登录号[98-51-1]）对完整神经系统功能的影响。接触4-叔丁基甲苯会引起闪光诱发电位幅度的变化。在接触停止后的第2天、19天和26天，这些变化与对照组有显著差异，但在第5天和12天没有。实验期间，各实验组间体重增加无显著差异。这些结果表明，反复接触20 ppm的4-叔丁基甲苯会导致以闪光诱发电位变化衡量的中枢神经系统功能持续改变。建议重新评估目前4-叔丁基甲苯10 ppm的阈限值。
Zotero 插件