Nylén P, Hagman M, Johnson A C
Department of Neuromedicine, National Institute of Occupational Health, Solna, Sweden.
Pharmacol Toxicol. 1994 Feb;74(2):116-23. doi: 10.1111/j.1600-0773.1994.tb01085.x.
Rats were exposed to n-hexane, toluene, or toluene together with n-hexane, each solvent 1000 p.p.m. (1000 + 1000 p.p.m. in combined exposure), 21 hr/day, 7 days/week during 28 days. Neurophysiological recordings were made 2 days, 3 months, and one year after end of exposure. A reduction in auditory sensitivity, recorded by click evoked auditory brainstem response, was observed 2 days after exposure to toluene alone, or to toluene together with n-hexane, but not after exposure to n-hexane alone. The reduction lasted one year after the exposure. Three months after combined exposure, a synergistic enhancement of loss of auditory sensitivity was observed in the mixed exposure group. One amplitude in the flash evoked potentials was lowered in the n-hexane exposed group 2 days after exposure. No such reduction was seen after simultaneous exposure to toluene. Exposure to n-hexane alone caused a marked decrease in peripheral nerve conduction velocity 2 days and 3 months after exposure, while exposure to n-hexane together with toluene had only a small effect on this velocity.
将大鼠暴露于正己烷、甲苯或甲苯与正己烷的混合环境中，每种溶剂浓度为1000 ppm（混合暴露时为1000 + 1000 ppm），每天21小时，每周7天，持续28天。在暴露结束后的2天、3个月和1年进行神经生理学记录。单独暴露于甲苯或甲苯与正己烷混合环境后2天，通过点击诱发听觉脑干反应记录到听觉敏感性降低，但单独暴露于正己烷后未出现这种情况。这种降低在暴露后持续了一年。混合暴露3个月后，在混合暴露组中观察到听觉敏感性丧失的协同增强。暴露于正己烷组在暴露后2天，闪光诱发电位中的一个振幅降低。同时暴露于甲苯后未出现这种降低。单独暴露于正己烷在暴露后2天和3个月导致外周神经传导速度显著降低，而暴露于正己烷与甲苯的混合环境对该速度只有轻微影响。
