Schmidt M, Wirtz H
Pneumologie an der Medizinischen Univ.-Klinik Würzburg.
Pneumologie. 1995 Mar;49(3):226-32.
On the whole, sarcoidosis of the lung has a good prognosis with the exception of a few cases where it takes a progressive course. In such instances it would be useful to enable a prognosis already at the time of diagnosis by means of clinical parameters or inflammation markers. We examined a number of cell-biological inflammation parameters in the serum and bronchoalveolar lavage fluid of 72 patients in the x-ray stages I and II with and without Löfgren's syndrome (phenotyping of lymphocytes, interleukin-1 alpha, soluble interleukin-2 receptors [sIL-2R], interleukin-6, interleukin-8, platelet-derived growth factor, procollagen-3 peptide) and followed up these patients for one year by clinical parameters. It was found that markers of the active lymphocytic inflammation were mostly associated with spontaneous remission during the follow-up period. Hence, acute lymphocytic inflammation is a favourable prognostic sign and should not prompt premature treatment with cortisone.
总体而言，除少数病例呈进行性病程外，肺部结节病预后良好。在此类情况下，借助临床参数或炎症标志物在诊断时就能做出预后判断将很有帮助。我们检测了72例处于X线分期I和II期、伴有或不伴有 Löfgren 综合征患者血清及支气管肺泡灌洗液中的多项细胞生物学炎症参数（淋巴细胞表型分析、白细胞介素-1α、可溶性白细胞介素-2受体[sIL-2R]、白细胞介素-6、白细胞介素-8、血小板衍生生长因子、前胶原-3肽），并通过临床参数对这些患者进行了为期一年的随访。结果发现，活跃淋巴细胞炎症的标志物大多与随访期间的自发缓解相关。因此，急性淋巴细胞炎症是一个良好的预后征象，不应过早促使使用皮质激素治疗。
