Tsutsumi T, Nagai S, Imai K, Setoyama Y, Uchiyama T, Izumi T
Chest Disease Research Institute, Kyoto University, Japan.
Sarcoidosis. 1994 Sep;11(2):102-9.
Soluble interleukin-2 receptor (sIL-2R) concentration is considered to reflect disease activity in patients with sarcoidosis. However, it remains to be evaluated whether or not the sIL-2R concentration reflects the total burden of granulomatous lesions, or if it can be a useful marker for other interstitial lung diseases such as IPF, the lesions of which are restricted to the lungs. In this study, we demonstrated that sIL-2R concentrations in 16 patients with active sarcoidosis increased (2031 +/- 1222 U/ml), compared to those in 29 patients with inactive disease (796 +/- 313), 24 with IPF (859 +/- 694) and 33 healthy controls (467 +/- 174). sIL-2R concentrations in patients with IPF also increased, more than those in healthy subjects. sIL-2R concentrations in 10 patients with extrathoracic lesions (ETL) were not different from those in 6 patients without ETL. Correlation between serum sIL-2R concentrations and serum ACE activity, BAL macrophage %, and BAL lymphocyte % was shown in patients with sarcoidosis. In patients with IPF, a correlation between sIL-2R concentrations and BAL macrophage % was found but there was no correlation between sIL-2R concentrations and BAL lymphocyte %. In conclusion, serum sIL-2R concentrations seem to reflect total inflammatory lesions. In addition, they reflect total inflammatory lesions of the lungs in sarcoidosis and IPF. For clinical purposes, its measurement may be more useful than that of BAL fluid concentrations in patients with sarcoidosis and IPF.
可溶性白细胞介素-2受体（sIL-2R）浓度被认为可反映结节病患者的疾病活动度。然而，sIL-2R浓度是否反映肉芽肿性病变的总体负担，或者它是否可作为其他间质性肺疾病（如特发性肺纤维化（IPF），其病变局限于肺部）的有用标志物，仍有待评估。在本研究中，我们证明，16例活动期结节病患者的sIL-2R浓度（2031±1222 U/ml）高于29例非活动期疾病患者（796±313）、24例IPF患者（859±694）和33例健康对照者（467±174）。IPF患者的sIL-2R浓度也升高，且高于健康受试者。10例有胸外病变（ETL）患者的sIL-2R浓度与6例无ETL患者的sIL-2R浓度无差异。结节病患者血清sIL-2R浓度与血清ACE活性、支气管肺泡灌洗（BAL）巨噬细胞百分比和BAL淋巴细胞百分比之间存在相关性。在IPF患者中，发现sIL-2R浓度与BAL巨噬细胞百分比之间存在相关性，但sIL-2R浓度与BAL淋巴细胞百分比之间无相关性。总之，血清sIL-2R浓度似乎反映了总的炎症性病变。此外，它们反映了结节病和IPF患者肺部的总的炎症性病变。出于临床目的，在结节病和IPF患者中，测量血清sIL-2R浓度可能比测量BAL液浓度更有用。
