Timoshenko A V, Gabius H J
Department of Biophysics, Belarusian State University, Minsk, Republic of Belarus.
Planta Med. 1995 Apr;61(2):130-3. doi: 10.1055/s-2006-958031.
Galactose-specific lectin from Viscum album (VAA) was shown to induce the aggregation of rat thymocytes, to increase the intracellular Ca(2+)-availability, and to enhance the menadione-dependent release of H2O2 from cells in a carbohydrate- and dose-dependent manner. This activity was mediated by the carbohydrate-binding B-subunit, whereas the toxic A-subunit failed to display aggregating activity or to affect the intracellular Ca2+. However, incubation of cells in its presence decreased the release of H2O2. These data extend the knowledge of the immunomodulatory potency of VAA, especially its carbohydrate-binding B chain.
槲寄生半乳糖特异性凝集素（VAA）可诱导大鼠胸腺细胞聚集，增加细胞内钙离子的可利用性，并以碳水化合物和剂量依赖的方式增强细胞中维生素K依赖的过氧化氢释放。该活性由碳水化合物结合性B亚基介导，而有毒的A亚基未表现出聚集活性或影响细胞内钙离子。然而，细胞在其存在下孵育会降低过氧化氢的释放。这些数据扩展了对VAA免疫调节效力的认识，特别是其碳水化合物结合性B链。
