Gasparini G, Jabbour A, Lanfrit G
Ospedale Clinicizzato, S. Donato S. Donato Milanese, Milano.
Radiol Med. 1995 Mar;89(3):229-32.
Computed Tomography scanners can be calibrated to provide reproducible measurements for the quantitative analysis of lung density. We measured in square centimeters the pulmonary density areas for each interval of values expressed in Hounsfield Units and obtained some histograms representing the "respiratory curves" for full inspiration and full expiration. The study population had been divided into three groups according to their clinical conditions. Group A: 12 normal subjects, aged 20-40, non-smokers; Group B: 23 patients, aged 40-65, smokers, asymptomatic or slightly asthmatic; Group C: 19 patients, aged 55-75 hospitalized with chronic obstructive pulmonary disease. The respiratory curves obtained at full expiration appeared to be completely different in the three groups resulting more significant than those obtained at full inspiration. We conclude that the histograms obtained by measuring the pulmonary density areas in full expiration at preselected intervals of HU values can be useful as a screening test as well as to quantify pulmonary emphysema.
计算机断层扫描（CT）扫描仪可进行校准，以便为肺密度的定量分析提供可重复的测量结果。我们以平方厘米为单位测量了以亨氏单位（HU）表示的每个值区间的肺密度面积，并获得了一些代表深吸气和深呼气时“呼吸曲线”的直方图。研究人群根据临床状况分为三组。A组：12名正常受试者，年龄20 - 40岁，非吸烟者；B组：23名患者，年龄40 - 65岁，吸烟者，无症状或轻度哮喘；C组：19名年龄55 - 75岁因慢性阻塞性肺疾病住院的患者。三组在深呼气时获得的呼吸曲线似乎完全不同，比深吸气时获得的曲线差异更显著。我们得出结论，通过在预先选定的HU值区间测量深呼气时的肺密度面积所获得的直方图，可作为一种筛查测试，也可用于量化肺气肿。
