来自大肠杆菌的野生型和抑制型色氨酸tRNA中的反密码子构象及可及性
Anticodon conformation and accessibility in wild-type and suppressor tryptophan tRNA from E. coli.
作者信息
Buckingham R H
出版信息
Nucleic Acids Res. 1976 Apr;3(4):965-75. doi: 10.1093/nar/3.4.965.
Abstract
The association between Trp-tRNA and Pro-tRNA, which have complementary anticodon sequences, has been used as a probe of anticodon conformation. It is unaffected, however, by the base change in the D-stem present in UGA-suppressor Trp-tRNA. This does not support the hypothesis that UGA suppression depends upon a conformational change induced in the anticodon. The stable denatured form of wild-type Trp-tRNA no longer interacts with Pro-tRNA; the structure of the anticodon region must therefore be quite different in the denatured form.
摘要
具有互补反密码子序列的色氨酸转运RNA（Trp-tRNA）和脯氨酸转运RNA（Pro-tRNA）之间的关联已被用作反密码子构象的探针。然而，它不受UGA抑制型色氨酸转运RNA中D茎碱基变化的影响。这并不支持UGA抑制依赖于反密码子中诱导的构象变化这一假设。野生型色氨酸转运RNA的稳定变性形式不再与脯氨酸转运RNA相互作用；因此，反密码子区域的结构在变性形式中必然有很大不同。
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