Wüthrich B
Dermatologische Klinik und Poliklinik, Universitätsspital Zürich.
Ther Umsch. 1995 Apr;52(4):282-7.
Paraneoplastic dermatoses or cutaneous paraneoplastic syndromes are a non neoplastic skin condition closely related to and in their manifestation directly influenced by an underlying malignancy. They are subdivided into two groups: one whose clinical picture reveals the presence of a malignant tumor and an association with a malign internal tumor in nearly 100%, and a second in which the possibility of a malignancy exists. Not included under the heading paraneoplastic dermatoses are changes with neoplastic cells appearing in the skin, tumors involving secondary illnesses, and genetically caused dermatologic syndromes accompanied by internal malignancies. Although the pathogenesis of the paraneoplastic dermatoses is very unclear, knowledge of these conditions is necessary, since it may in rare instances lead to an early diagnosis of a malignant tumor. On the other hand, only treatment of the underlying disease can improve the dermatoses.
副肿瘤性皮肤病或皮肤副肿瘤综合征是一种与潜在恶性肿瘤密切相关且其表现直接受其影响的非肿瘤性皮肤疾病。它们可分为两组:一组临床表现几乎100%显示存在恶性肿瘤且与恶性内部肿瘤相关;另一组存在恶性肿瘤的可能性。皮肤出现肿瘤细胞的变化、伴有继发性疾病的肿瘤以及伴有内部恶性肿瘤的遗传性皮肤病综合征不属于副肿瘤性皮肤病范畴。尽管副肿瘤性皮肤病的发病机制尚不清楚,但了解这些疾病是必要的,因为在极少数情况下可能有助于早期诊断恶性肿瘤。另一方面,只有治疗基础疾病才能改善皮肤病。