Cornu C, Poitevin B, Lion L, Gillet J, Collet J P, Poncet J E, Chaufferin G, Boissel J P
Service de Pharmacologie Clinique, Lyon, France.
Therapie. 1995 Jan-Feb;50(1):41-5.
We performed a survey to assess the feasibility of a placebo-controlled clinical trial of the treatment of recurrent ENT/respiratory tract infections in children, to assess the diversity of the drugs prescribed, and the acceptability of a clinical trial to homeopathic physicians. A mailed questionnaire was sent to 237 homeopathic physicians, asking for details of prescriptions for 10 consecutive children consulting for ENT/respiratory recurrent infections, and for two simulated cases. We also asked for their opinion about homeopathic treatment evaluation. Only 48 (20 per cent) questionnaires were returned completed. These gave 309 different acute treatments and 422 different preventive treatments for the 10 consecutive patients and 87 different prescriptions for the simulated cases. A total of 467 different drugs were used. The physicians who replied were favourable to the evaluation of homeopathic drugs, reluctant for the use of a placebo; and they would like to receive training in drug evaluation. Setting up a clinical trial in this field would require specific methodological and logistical adaptations, and a detailed training programme for the homeopathic doctors beforehand.
我们开展了一项调查，以评估针对儿童复发性耳鼻喉/呼吸道感染进行安慰剂对照临床试验的可行性，评估所开药物的多样性，以及顺势疗法医生对临床试验的接受程度。我们向237名顺势疗法医生发送了一份邮寄问卷，询问他们为连续10名因耳鼻喉/呼吸道反复感染前来咨询的儿童以及两个模拟病例所开处方的详细信息。我们还询问了他们对顺势疗法治疗评估的看法。仅48份（20%）问卷被完整返还。这些问卷为连续10名患者提供了309种不同的急性治疗方法和422种不同的预防性治疗方法，为模拟病例提供了87种不同的处方。总共使用了467种不同的药物。回复问卷的医生对顺势疗法药物评估持支持态度，不愿使用安慰剂；他们希望接受药物评估方面的培训。在该领域开展临床试验需要进行特定的方法学和后勤调整，并事先为顺势疗法医生制定详细的培训计划。
