Walters E T, Ambron R T
Dept of Physiology and Cell Biology, University of Texas Medical School, Houston 77030, USA.
Trends Neurosci. 1995 Mar;18(3):137-42. doi: 10.1016/0166-2236(95)93891-z.
Bodily injury in Aplysia, as in mammals, produces long-lasting memory traces at various neural loci. One consequence of injury, damage to peripheral axons, produces long-term hyperexcitability, synaptic facilitation, and growth in Aplysia sensory neurons. Similar effects are induced in these cells by repeated exposure to 5-HT that is released during aversive learning. An interesting question is to what extent cellular pathways that mediate the effects of axonal injury and 5-HT overlap. One current focus is on identifying cytoplasmic signals that initiate persistent sensory alterations that contribute to both long-term sensitization and memory of injury.
与哺乳动物一样，海兔的身体损伤会在多个神经位点产生持久的记忆痕迹。损伤的一个后果是外周轴突受损，这会导致海兔感觉神经元长期的过度兴奋、突触易化和生长。在厌恶学习过程中释放的5-羟色胺（5-HT）反复作用于这些细胞，也会诱导出类似的效果。一个有趣的问题是，介导轴突损伤和5-羟色胺作用的细胞通路在多大程度上重叠。目前的一个研究重点是确定引发持续性感觉改变的细胞质信号，这些改变有助于长期敏感化和损伤记忆。
