Franklin R J, Blakemore W F
MRC Cambridge Centre for Brain Repair, University of Cambridge, UK.
Trends Neurosci. 1995 Mar;18(3):151-6. doi: 10.1016/0166-2236(95)93893-3.
The close association that exists between development and regeneration stems from the many shared functions and the similar mechanisms by which these functions are achieved. For this reason, advances made in developmental neurobiology have provided important insights for neurobiologists interested in repair of the damaged CNS. Through the technique of transplantation, it has been possible to demonstrate that the differentiation of the 'O-2A' glial progenitor cell in vitro into oligodendrocytes and astrocytes described initially by developmental biologists can also occur within pathological states of the adult CNS.
发育与再生之间存在的紧密联系源于许多共同的功能以及实现这些功能的相似机制。因此，发育神经生物学取得的进展为对受损中枢神经系统修复感兴趣的神经生物学家提供了重要的见解。通过移植技术，已经能够证明发育生物学家最初描述的“O-2A”神经胶质祖细胞在体外分化为少突胶质细胞和星形胶质细胞的过程，在成体中枢神经系统的病理状态下也会发生。
