Shung K K, Flenniken R R
Bioengineering Program, Pennsylvania State University, University Park 16802, USA.
Ultrasound Med Biol. 1995;21(1):71-8. doi: 10.1016/0301-5629(94)00096-4.
Time-domain ultrasonic blood flow estimation methods have recently received considerable attention because of their advantages over conventional Doppler methods. Among them are that they may yield better spatial resolution and that methods based on frame-to-frame speckle tracking do not require a knowledge of the angle between directions of blood flow and the ultrasound beam. These methods, however, suffer from an intrinsic problem of poor signal-to-noise ratio, since the echoes scattered back by blood are much weaker than those of the surrounding structures. In addition, the maximal velocity that can be estimated by frame-to-frame tracking via conventional ultrasonic scanners is limited by the frame rate of the scanner. In this article, we will present experimental results to show that these problems may be alleviated by using a high frame rate scanner in conjunction with the injection of an ultrasonic contrast agent. In this study the contrast agent used was Albunex.
时域超声血流估计方法因其相对于传统多普勒方法的优势，近来受到了广泛关注。其中包括它们可能产生更好的空间分辨率，以及基于逐帧散斑跟踪的方法不需要了解血流方向与超声束之间的夹角。然而，这些方法存在一个固有的信噪比差的问题，因为血液散射回的回波比周围结构的回波要弱得多。此外，通过传统超声扫描仪进行逐帧跟踪所能估计的最大速度受扫描仪帧率的限制。在本文中，我们将展示实验结果，表明通过使用高帧率扫描仪并注入超声造影剂，可以缓解这些问题。在本研究中使用的造影剂是Albunex。
