Stolte M, Bethke B, Seifert E, Armbrecht U, Lütke A, Goldbrunner P, Rabast U
Institut für Pathologie, Klinikum Bayreuth.
Z Gastroenterol. 1995 Mar;33(3):146-9.
In patients undergoing long-term treatment with omeprazole, tiny gastric polyps, described histologically as glandular cysts, have occasionally been reported. We report on a further nine patients (5 women and 4 men) undergoing omeprazole treatment who developed endoscopically visible and histologically verified glandular cysts. Eight patients were on long-term treatment with omeprazole for reflux oesophagitis, and the glandular cysts were observed between 8 and 60 months after the start of treatment. In one patient with an NSAID-induced ulcer, a tiny polyp was found only three weeks after initiation of treatment. None of the patients had Helicobacter pylori-associated gastritis. The cysts, which measured between 0.25 and 0.7 mm in diameter, were mostly lined with flattened parietal and chief cells, but in three cases also with foveolar epithelium, so that they could not be reliably distinguished from Elster's gastric glandular cysts. These glandular cysts are harmless, and do not require further diagnostic or therapeutic measures. They probably develop spontaneously independently of the omeprazole therapy.
在接受奥美拉唑长期治疗的患者中，偶尔会报告有组织学上描述为腺性囊肿的微小胃息肉。我们报告了另外9例接受奥美拉唑治疗的患者（5名女性和4名男性），他们经内镜可见并经组织学证实患有腺性囊肿。8例患者因反流性食管炎接受奥美拉唑长期治疗，腺性囊肿在治疗开始后的8至60个月之间被观察到。在1例非甾体抗炎药引起的溃疡患者中，治疗开始仅3周后就发现了一个微小息肉。所有患者均无幽门螺杆菌相关性胃炎。这些囊肿直径在0.25至0.7毫米之间，大多内衬扁平的壁细胞和主细胞，但在3例中也有小凹上皮，因此无法可靠地与埃尔斯特胃腺性囊肿区分开来。这些腺性囊肿无害，不需要进一步的诊断或治疗措施。它们可能与奥美拉唑治疗无关而自发形成。
