Williams T L, Shaw P J, Lowe J, Bates D, Ince P G
Division of Clinical Neuroscience, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
Acta Neuropathol. 1995;89(3):275-83. doi: 10.1007/BF00309344.
This report describes a patient who had clinical features of both motor neuron disease and Parkinson's disease. Neuropathological examination and immunocytochemical studies showed that he had motor neuron disease of the progressive muscular atrophy type, and Lewy body Parkinson's disease, with intracytoplasmic inclusion bodies characteristic of both conditions. This is the first detailed description of these two diseases occurring concurrently in the same patient. A review of all previously reported cases of combined motor neuron disease and parkinsonism has led to the following conclusions: (1) that these two neuropathologically defined diseases occur together very infrequently, but (2) that parkinsonism and substantia nigra degeneration are not uncommon as part of the multi-system disease process underlying motor neuron disease.
本报告描述了一名同时具有运动神经元病和帕金森病临床特征的患者。神经病理学检查和免疫细胞化学研究表明，他患有进行性肌萎缩型运动神经元病和路易体帕金森病，伴有两种疾病特有的胞质内包涵体。这是首次对同一患者同时发生这两种疾病的详细描述。对所有先前报道的运动神经元病合并帕金森综合征病例的回顾得出以下结论：（1）这两种神经病理学定义的疾病同时发生的情况非常罕见，但（2）帕金森综合征和黑质变性作为运动神经元病潜在多系统疾病过程的一部分并不少见。
