Asami T, Sakurai M
Department of Pediatrics, School of Medicine, Niigata University Hospital, Japan.
Acta Paediatr Jpn. 1995 Feb;37(1):75-7. doi: 10.1111/j.1442-200x.1995.tb03691.x.
We treated a sixteen month old male with chronic refractory idiopathic thrombocytopenic purpura (ITP) in whom alpha-interferon (IFN) therapy was effective. He developed ITP which did not respond to various treatments. Six months after admission, we began to treat him with IFN. The patient's platelet count rapidly responded to the therapy and rose above normal range. Serum levels of platelet associated immunoglobulin G (PA-IgG) showed a tendency to decrease with the administration of IFN. After stopping the IFN therapy for a duration of 3 months, the platelet count remained normal. No serious adverse side effects, except transient fever, were observed. From the experience of this case we propose that IFN is one of the therapeutic options for treatment of refractory ITP not only in adults but also in children.
我们治疗了一名16个月大的患有慢性难治性特发性血小板减少性紫癜（ITP）的男性患儿，α干扰素（IFN）治疗对其有效。他患的ITP对各种治疗均无反应。入院6个月后，我们开始用IFN对他进行治疗。患者的血小板计数对该治疗迅速产生反应并升至正常范围以上。血小板相关免疫球蛋白G（PA-IgG）的血清水平显示随着IFN的给药有下降趋势。在停止IFN治疗3个月后，血小板计数仍保持正常。除了短暂发热外，未观察到严重的不良副作用。从该病例的经验来看，我们提出IFN不仅是治疗成人难治性ITP的治疗选择之一，也是治疗儿童难治性ITP的治疗选择之一。
