Kumakura S, Ishikura H, Tsumura H, Endo J, Tsunematsu T
Third Division of Internal Medicine, Shimane Medical University, Izumo, Japan.
Br J Haematol. 1993 Dec;85(4):805-7. doi: 10.1111/j.1365-2141.1993.tb03228.x.
We successfully treated two patients with refractory idiopathic thrombocytopenic purpura (ITP) with a weekly or monthly administration of alpha-interferon followed by short-course treatment with alpha-interferon. In both cases an increase in platelet count was brought about within 1 week after administration of alpha-interferon and the favourable response in platelet count was sustained over a few years with the weekly or monthly administration of alpha-interferon in the absence of any noticeable side-effects except for fever. So, alpha-interferon therapy seems to be beneficial in some cases of refractory ITP in terms of both remission induction and maintenance therapy.
我们通过每周或每月一次给予α干扰素，随后进行α干扰素短程治疗，成功治疗了两名难治性特发性血小板减少性紫癜（ITP）患者。在这两例患者中，给予α干扰素后1周内血小板计数均升高，并且在数年中，通过每周或每月给予α干扰素，血小板计数保持良好反应，除发热外无任何明显副作用。因此，就诱导缓解和维持治疗而言，α干扰素治疗在某些难治性ITP病例中似乎是有益的。
