Siché J P, Schwebel C, Longère P, Tremel F, de Gaudemaris R, Comparat V, Mallion J M
Service de médecine interne et cardiologie, CHU Grenoble.
Arch Mal Coeur Vaiss. 1994 Aug;87(8):1005-9.
To study the relationship between assessment of blood pressure (BP) variability measured by continuous measurement (Finapres) or discontinuous ambulatory (ABPM Spacelabs) in 70 untreated essential hypertensive subjects (mean age 51 +/- 12) and their relationship with the development of left ventricular hypertrophy (LVH). There is no relationship between the BP variability measurements either by Finapres nor by ABPM. Multiple regression analysis show that ambulatory systolic BP variability (standard deviation) and resting BP variability (spectral analysis of SBP in the medium frequency band 0.1 Hz) are related to LVH index when we take into account age and BP difference (to explain LVH) (p < 0.001) ABPM SBP variability increase with LVH, while resting SBP measurement of BP variability (Mayer waves) significantly decreased. The study points to the different role of BP variability measurements in the mechanisms related to left ventricular hypertrophy and to the interest of continuous BP resting spectral analysis measurements.
为研究70例未经治疗的原发性高血压患者（平均年龄51±12岁）通过连续测量（Finapres）或间断动态测量（ABPM Spacelabs）所测得的血压（BP）变异性之间的关系，以及它们与左心室肥厚（LVH）发生之间的关系。通过Finapres或ABPM进行的血压变异性测量之间没有关系。多元回归分析表明，当考虑年龄和血压差异（用于解释LVH）时，动态收缩压变异性（标准差）和静息血压变异性（0.1Hz中频带收缩压的频谱分析）与LVH指数相关（p<0.001）。ABPM收缩压变异性随LVH增加，而静息收缩压的血压变异性测量（迈耶波）显著降低。该研究指出了血压变异性测量在与左心室肥厚相关机制中的不同作用，以及连续血压静息频谱分析测量的意义。
