Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-Ku,Yokohama, Japan.
Clin Exp Hypertens. 2009 Nov;31(8):669-79. doi: 10.3109/10641960903407033.
Blood pressure (BP) variability is calculated as the standard deviation of ambulatory BP. Blood pressure variability is associated with the cardiovascular morbidity; however whether it is related to target organ damage is controversial. In this study we examined a possible relationship between the BP variability and left ventricular hypertrophy (LVH), and between BP variability and brachial-ankle pulse wave velocity (baPWV). The present study was conducted on 111 consecutive Japanese hypertensive patients who were hospitalized for the educational program in our hospital under stable sodium chloride intake (6 g/day). Blood pressure measurements were at 30-minute intervals all day. In a multivariable analysis adjusted with confounding factor, LVH was associated with 24-hour systolic BP (SBP), 24 hour diastolic BP (DBP), daytime SBP, daytime DBP, nighttime SBP, and nighttime DBP. Additionally, nighttime DBP variability was related to LVH. By the same method, baPWV as a dependent variable was related to 24-hour SBP and nighttime SBP. Furthermore, nighttime SBP variability was concerned with baPWV. The LVH was associated with not only BP level but also with nighttime DBP variability. The baPWV was also related not only to BP level but also to nighttime SBP variability.
血压变异性是通过测量动态血压的标准差来计算的。血压变异性与心血管发病率有关；然而，它与靶器官损伤是否有关仍存在争议。在这项研究中，我们研究了血压变异性与左心室肥厚（LVH）之间以及血压变异性与臂踝脉搏波速度（baPWV）之间的可能关系。本研究纳入了 111 例连续的日本高血压患者，这些患者在我院接受稳定的氯化钠摄入量（6g/天）的教育计划住院。全天每隔 30 分钟测量一次血压。在调整了混杂因素的多变量分析中，LVH 与 24 小时收缩压（SBP）、24 小时舒张压（DBP）、白天 SBP、白天 DBP、夜间 SBP 和夜间 DBP 相关。此外，夜间 DBP 变异性与 LVH 相关。通过同样的方法，baPWV 作为因变量与 24 小时 SBP 和夜间 SBP 相关。此外，夜间 SBP 变异性与 baPWV 有关。LVH 不仅与血压水平有关，还与夜间 DBP 变异性有关。baPWV 不仅与血压水平有关，还与夜间 SBP 变异性有关。
